Hypogonadotropic hypogonadism (HH) is the situation of lack of the Gonadotropin Releasing Hormone (GnRH) release from hypothalamus or the inadequate response of the hypophysis gland to the GnRH stimulation. Congenital HH is a rare clinical situation which exhibits itself with low sex hormone levels. Patients mostly present with amenorrhea, delayed puberty, infertility. Pregnancy can be achieved by ensuring ovulation with GnRH or gonadotropin replacement. The multiple pregnancy rates following ovulation have been reported between 20% and 50%. Diabetes, anemia, amniotic fluid abnormalities, pregnancy-related hypertension, eclampsia, cervical insufficiency, placenta previa, the use of tocolysis, twin to twin transfusion, preterm and cesarean delivery rates are increased among high order pregnancies.

Authors: Ezgi TURGUT, Burak AKSELIM, Oktay KAYMAK, Yetkin KARASU, Yusuf ERGUN

Key Words: Hypogonadotropic hypogonadism; triplet pregnancy; intrauterine insemination; multiple pregnancies