Uterine leiomyosarcoma (ULMS) is a rare uterine malignancy that is aggressive and typically spreads to the lungs and liver hematogenously. However, it may recur with seeding to the peritoneal surfaces, of which the prognosis is historically dismal. ULMS with peritoneal dissemination has limited treatment options. We report a case of uterine leiomyosarcoma in which the patient underwent previous debulking surgery but developed recurrence with peritoneal sarcomatosis 7 months later. She underwent cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin 16mg (0.32mg/kg) but had tumour recurrence 5 months later. This report presents a case of CRS and HIPEC performed for a patient with recurrent ULMS with peritoneal dissemination and a review of the literature on CRS and HIPEC for ULMS with peritoneal sarcomatosis.

Authors: Lionel Chen, Melissa Teo

Key Words: Uterus, leiomyosarcoma, cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC)